感染症治療を考える素材を提供します。最近は意思決定への応用が関心領域。双子と0歳の育児奮闘中。I have Ph.D. but less sense a ID pharmacist (ICPS). Another face is an investor.


大人 熱射病 up to dateとワシントンマニュアルより



















Body temperature is maintained within a narrow range by balancing heat load with heat dissipation. Evaporation is the principal mechanism of heat loss in a hot environment, but becomes ineffective above a relative humidity of 75 percent. The other major methods of heat dissipation, including conduction and convection, cannot efficiently transfer heat when environmental temperature exceeds skin temperature. 


The differential diagnosis of hyperthermia is extensive and includes infectious, endocrine, central nervous system, and toxic etiologies. The most important causes of severe hyperthermia (greater than 40ºC [or 104ºF]) caused by a failure of thermoregulation are heat stroke, neuroleptic malignant syndrome, and malignant hyperthermia. 



Severe nonexertional hyperthermia (classic heat stroke) carries a high mortality rate. Mortality correlates with the degree of temperature elevation, time to initiation of cooling measures, and the number of organ systems affected.


The diagnosis of nonexertional heat stroke is made clinically based upon an elevated core body temperature (generally >40°C), central nervous system dysfunction (eg, altered mental status), exposure to severe environmental heat, and the absence of another explanation for hyperthermia. Patients with classic heat stroke generally have increased susceptibility to the heat due to age or underlying medical conditions. Diagnostic studies are generally nonspecific but may reflect cardiovascular, renal, or hepatic dysfunction, or coagulopathy. Studies to be obtained are described in the text.


The management of nonexertional heat stroke consists of ensuring adequate airway protection, breathing, and circulation; rapid cooling; and treatment of complications. Tracheal intubation and mechanical ventilation are often necessary. Hypotension or volume depletion is treated with discrete intravenous boluses of isotonic crystalloid; alpha-adrenergic agonists should be avoided if possible.


We suggest that rapid cooling of patients with nonexertional heat stroke be performed using evaporative and convective techniques (Grade 2C). Evaporative and convective cooling techniques are safe and effective in nonexertional heat stroke and do not interfere with patient access or monitoring, or other treatments. Cold water immersion may be harmful to elder patients; there is no role for antipyretic agents. Continuous core temperature monitoring with a rectal or esophageal probe is mandatory in all patients being treated for heat stroke. The management of exertional heat stroke is discussed separately.


Nonexertional heat stroke can cause a number of complications, including respiratory and cardiac dysfunction, hypotension, seizures, rhabdomyolysis, acute renal and hepatic injury, and disseminated intravascular coagulation. 


Cooling measures 


Evaporative and convective cooling is the method used most often to treat classic heat stroke because it is effective, noninvasive, easily performed, and does not interfere with other aspects of patient care. When used to treat elderly patients with classic heat stroke, evaporative and convective cooling is associated with decreased morbidity and mortality.

With evaporative and convective cooling, the naked patient is sprayed with a mist of lukewarm water while fans are used to blow air over the moist skin. Special beds called body cooling units have been made for this purpose [4]. Agitation from an altered mental status or shivering induced by evaporative and convective cooling or other treatments may generate heat and can be suppressed with short-acting IV benzodiazepines, such as lorazepam (1 to 2 mg IV). Benzodiazepines may also improve core body cooling. If neuroleptic malignant syndrome (NMS) is not suspected and benzodiazepines are ineffective at controlling shivering, chlorpromazine (25 to 50 mg IV) may be used. However, chlorpromazine has anticholinergic properties and thus, may impair sweating and exacerbate hypotension. 

Other effective cooling methods are less commonly used in patients with classic heat stroke. Immersing the patient in ice water (cold water immersion) is an efficient, noninvasive method of rapid cooling [40], but it complicates monitoring and intravenous access, and may be harmful to elder patients [4]. An alternative method that allows greater access to the patient is water ice therapy (WIT), in which the patient is placed supine on a porous stretcher positioned on top of a tub of ice water. Medical personnel continuously pour ice water from the bath onto the patient and massage major muscle groups with ice packs to increase skin vasodilation. Applying ice packs to the axillae, neck, and groin (areas adjacent to major blood vessels) is another effective cooling technique, but may be poorly tolerated by the awake patient. A small randomized trial, in healthy subjects with exercise-induced hyperthermia, reported that applying cold compresses to the glabrous (smooth, hairless) skin surfaces of the cheeks, palms, and soles led to more rapid cooling than applying them to the axillae, neck, and groin. This approach warrants further study in classic heat stroke patients with comorbidities that might impair peripheral vasodilatation.

Cold thoracic and peritoneal lavage results in rapid cooling. However, it is invasive and peritoneal lavage is contraindicated in pregnant patients and those with previous abdominal surgery. Cooled oxygen, cooling blankets, and cold (ie, room temperature, or approximately 22°C [71.6°F]) intravenous fluids may be helpful adjuncts. Cold gastric lavage may cause water intoxication.

Recommendations for the treatment of heat stroke are based primarily upon small observational studies. A systematic review of clinical studies investigating the treatment of heat stroke noted the following]:

There are no definitive studies supporting any particular approach to cooling in classic heat stroke.


Evaporative and convective cooling methods for the treatment of classic heat stroke are better tolerated.


Immersion in ice water is rapid and effective in young patients with exertional heat stroke. However, immersion therapy is associated with increased mortality when used to treat elderly patients with classic heat stroke.


Pharmacologic therapy (eg, dantrolene) is ineffective and not indicated in the treatment of exertional or classic heat stroke.


Alcohol sponge baths should be avoided because large amounts of the drug may be absorbed through dilated cutaneous vessels and produce toxicity.


Pharmacologic therapy 


Pharmacologic therapy is not required in heat stroke. There is no role for antipyretic agents such as acetaminophen or aspirin in the management of heat stroke, since the underlying mechanism does not involve a change in the hypothalamic set-point and these medications may exacerbate complications such as hepatic injury or disseminated intravascular coagulation (DIC).

Salicylates can contribute to hyperthermia by uncoupling oxidative phosphorylation. Dantrolene is ineffective in patients with severe temperature elevation not caused by malignant hyperthermia. In cases where the etiology of the patient’s hyperthermia is unclear initially and infection remains a possibility, empiric administration of an initial dose of antibiotics, following collection of appropriate cultures, is prudent, while cooling measures are implemented.


What is heat stroke? 

Heat stroke is a condition that can happen when a person's body gets too hot. Most often, heat stroke happens when people exercise in very hot and humid weather without drinking enough fluids. But heat stroke can also happen in people who are not exercising. It is especially likely to affect older people and people who have health problems, so they need to be extra careful in hot conditions.

Heat stroke is a medical emergency that needs to be treated quickly. That's because heat stroke can lead to death if it is not treated quickly.

When people get too hot, they can also get "heat cramps" and "heat exhaustion." These conditions are not as serious as heat stroke, but they can lead to heat stroke if they aren't treated.

What are the symptoms of heat stroke? 


 People with heat stroke have:


A body temperature of 104°F (40°C) or higher


Brain symptoms – These can include:


Confusion or trouble thinking clearly

Seeing or hearing things that aren't real (called "hallucinating")

Trouble walking


Passing out


Heat stroke can also cause:


Fast breathing or a fast heartbeat

Skin redness and warmth

Vomiting or diarrhea

Muscle cramps or weakness



Should I see a doctor or nurse? 

Yes. If you or someone you are with has heat stroke, get medical help right away. 

Is there a test for heat stroke? 

Yes. The doctor will do an exam and take your temperature. He or she will probably do other tests to check if the heat stroke hurt other organs in your body. These tests can include:

Blood tests

Urine tests

Chest X-ray

Electrocardiogram (ECG) – This test measures the electrical activity in your heart (figure 1).


How is heat stroke treated? 

The main treatment involves cooling your body down. Your doctor can do this in the hospital in different ways.

Your doctor will also treat any other problems the heat stroke has caused.

Can heat stroke be prevented? 

Yes. When it is hot or humid out, you can do the following things to prevent heat stroke:

Try not to be too active, and take breaks when you exercise.


Drink enough fluids, such as water or sports drinks, so you do not feel thirsty. But don't force yourself to drink very large amounts in a short time, and don't drink so much that you feel uncomfortable. This can be harmful.


Do any exercise early in the day, before it gets too hot out.


Wear loose, lightweight clothes. Don't wear too many layers.


Avoid being in a hot car.


You should also watch for symptoms of heat cramps or heat exhaustion. Heat cramps cause painful muscle cramps. Heat exhaustion can cause headaches, dizziness, nausea, or vomiting. It can also make you thirsty or tired.

If you have symptoms of heat cramps or heat exhaustion, you should cool your body down right away to avoid getting heat stroke.

To cool your body down, you can:

Spray yourself with cool water and then sit in front of a fan.

Move into the shade, or go into an air-conditioned building or car.

Take a cool shower or bath.

Drink water or a sports drink. Do not have a drink with alcohol or caffeine.

Take off any extra clothing you are wearing.

Put a cold pack or cool cloth on your neck or armpit.