akinohanayuki ブログ

学位を持っても、センスのない、感染制御専門薬剤師のブログ.  I have Ph.D. but less sense ID pharmacist.

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

この研究は、素晴らしいです。しかし、ポリファーマシーに難しく影響します…

以下、荒削りPECO
 

A Randomized Trial of Intensive versus Standard Blood-Pressure Control
Article Tools
 
The SPRINT Research Group
 
NEJM
November 9, 2015
 
P
Age > 50
9361 persons with a systolic blood pressure of 130 mm Hg or higher and an increased cardiovascular risk, but without diabetes
 
E
systolic blood-pressure target of less than 120 mm Hg (intensive treatment) 
 
At 1 year, the mean systolic blood pressure was 121.4 mm Hg in the intensive-treatment group 
 
2.8 medications 
 
C
systolic blood-pressure a target of less than 140 mm Hg (standard treatment)
 
At 1 year, the mean systolic blood pressure was 136.2 mm Hg in the standard-treatment group.
 
1.8 medications
 
O
 primary composite outcome (myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes) in the intensive-treatment group than in the standard-treatment group (1.65% per year vs. 2.19% per year; hazard ratio with intensive treatment, 0.75; 95% confidence interval [CI], 0.64 to 0.89; P<0.001).
 
 All-cause mortality was also significantly lower in the intensive-treatment group (hazard ratio, 0.73; 95% CI, 0.60 to 0.90; P=0.003). 
 
Rates of serious adverse events of hypotension, syncope, electrolyte abnormalities, and acute kidney injury or failure, but not of injurious falls, were higher in the intensive-treatment group than in the standard-treatment group.
 
T
SPRINT was a randomized, controlled, open-label trial that was conducted at 102 clinical sites