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akinohanayuki日記

自分が興味あることを書いています. 主に感染領域. 二次利用は自己責任でお願いします. 博士(薬学). 感染制御専門薬剤師.

心血管以外のスタチンの利益って?

またまた、スタチンについて!

 
UpToDate引用を中心に復習

 

はじめに
Lipid lowering, at least with statins, is beneficial in patients with dyslipidemias for both primary and secondary prevention of coronary heart disease.
 
可能性…
A number of noncardiovascular benefits to statin therapy have been suggested. Many of these reflect associations in observational studies and may be due to confounding and/or bias.
 
ガンを増やしも減らしもしない
Statins do not appear to increase or decrease the risk of cancer.
 
痴呆は…少し遅らせるかも⁉︎
Some observational studies have suggested that statins may decrease the risk of dementia and at least one small randomized trial has suggested that statins may slow the progression of dementia.
 
中等度の慢性腎障害患者にはいいかも⁉︎
Post-hoc analyses of clinical trials have raised the possibility that statins may be of some benefit in preserving renal function, both in patients with moderate chronic renal insufficiency and in patients with normal renal function.
 
肺炎は…敗血症は…
 
JUPITER trial
risk of incident pneumonia (HR0.83, CI 0.69-1.00)
risk of sepsis (HR 1.21, CI 0.82-1.78)
all infections (HR 0.98, CI 0.94-1.03)
severe infections (HR 0.90, CI 0.79-1.03)
 
Systematic review and meta-analysis of randomised placebo controlled trials.
11 randomized trials of statins (n = 30,947) found no effect of statin therapy on infections (relative risk [RR] 1.00, 95% CI 0.96-1.05) or infection related mortality (RR 0.97, CI 0.83-1.13)
 
スタチンは謎ですね…
続きはまた後で!