akinohanayuki ブログ

学位を持っても、センスのない、感染制御専門薬剤師のブログ.  I have Ph.D. but less sense ID pharmacist.

RCT

Journal Club : Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer

今週のプレゼンターは、呼吸器内科医です。 2017年6月NEJMに発表された、 ALK陽性 非小細胞がんに対するアレクチニブ vs クリゾチニブの第3相RCT。 www.ncbi.nlm.nih.gov

Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial.

Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial. www.ncbi.nlm.nih.gov 2013年JACに報告された、スイス単…

Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii: a multicenter, randomized clinical trial.

Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii: a multicenter, randomized clinical trial. www.ncbi.nlm.nih.gov 2013年CIDに報告された、…

Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial.

Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. www.ncbi.nlm.nih.gov 2013年 CID に報告された、オーストラリアと香港の5施設ICUによる重症sepsisに対しするベータラクタム…

Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial.

Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial. www.ncbi.nlm.nih.gov 2017年5月 JAMA に報告された、米国5施設による単純性蜂窩織炎に対しす…

Journal Club : A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy.

Journal Club : A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. www.ncbi.nlm.nih.gov 今週のプレゼンターは、私です。 …

Journal Club : SALTO ; Randomised phase III trial of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer: SALTO study by the Dutch Colorectal Cancer Group.

Journal Club : SALTO ; Randomised phase III trial of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer: SALTO study by the Dutch Colorectal Cancer Group. www.ncbi.nlm.nih.gov 今週のプレゼンターは、薬学部5…

Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial.

Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. www.ncbi.nlm.nih.gov 2016年5月 Lancet Inf Dis に報告された、オランダ15施…

SOLO I : Single-dose oritavancin in the treatment of acute bacterial skin infections.

SOLO I : Single-dose oritavancin in the treatment of acute bacterial skin infections. www.ncbi.nlm.nih.gov 2014年 NEJMに報告された、急性細菌性皮膚/皮膚組織感染症に対するoritavancinとvancomycinを比較したRCT。

ESTABLISH-2 : Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.

ESTABLISH-2 : Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial. www.ncbi.nlm.nih.gov 2014年 Lancet Inf Disに…

ESTABLISH-1 : Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial.

ESTABLISH-1 : Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial. www.ncbi.nlm.nih.gov 2013年 JAMAに報告された、国際共同(アジアは含まれない)81施設 による…

Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women.

RCT

Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women. www.ncbi.nlm.nih.gov 2011年 Arch Intern Medに報告された、オランダにおける再発性尿路感染症を有する閉経前…

Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.

Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. 2016年 JAMAに報告された、米国nursing home 21施設における高齢者細菌尿・膿尿に対するクランベリーカプセル vs プラセボを比…

Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial.

Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenicvertebral osteomyelitis: an open-label, non-inferiority, randomised, controlledtrial. 2015年 (Epub2014年) Lancetに報告された、フランス71施設における化膿性脊椎炎患者…

Journal Club : MODIFY I and MODIFY II ; Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

Journal Club : Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection. MODIFY I and MODIFY II 今週のプレゼンターは、感染症看護専門看護師 2017年1月NEJMに報告された、日本を含む30カ国322施設におけるC. difficile の初感染また…

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. www.ncbi.nlm.nih.gov 2015年JAMAに報告された、スペイン3施設によ…

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. www.ncbi.nlm.nih.gov 2015年Lancetに報告された、スイス7施設による成人の市中肺炎に対するプレドニゾ…

Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL).

SOLITAIRE-ORAL : Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial. www.ncb…

Antibiotic treatment strategies for community-acquired pneumonia in adults.

CAP-START : Antibiotic treatment strategies for community-acquired pneumonia in adults. www.ncbi.nlm.nih.gov 2015年NEJMに報告された、オランダ7施設による成人の市中肺炎に対する抗菌薬治療戦略.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. www.ncbi.nlm.nih.gov 2016年JAMAに報告された、カナダ6施設によるCDI…

Simvastatin in the acute respiratory distress syndrome

Simvastatin in the acute respiratory distress syndrome www.ncbi.nlm.nih.gov 2014年NEJMに報告された、英国40施設ICUによるARDSに対するスタチンRCT。

Journal Club : Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial. ALTA trial

Journal Club : Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial. www.ncbi.nlm.nih.gov 今週のプレゼンターは、呼吸器内科医 2017年JCOに…

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial. www.ncbi.nlm.nih.gov 2016年CIDに報告された、ベトナム2施設によるデング熱に対するRCT。 スタチンとプラセボの比較。スタチンの抗炎…

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. www.ncbi.nlm.nih.gov 2015年NEJMに報告された、米国4施設による単純性皮膚感染症に対するRCT。 クラシカルなSTとクリンダマイシン比較。

Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess.

Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. www.ncbi.nlm.nih.gov 2016年NEJMに報告された、米国5施設による単純性皮膚膿瘍に対するRCT。 クラシカルなSTのプラセボ比較。

CAMERA : Combination of Vancomycin and β-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial.

CAMERA study Combination of Vancomycin and β-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial. オーストラリア7施設によるMRSA菌血症に対する併用療法パイロットRCT 新薬…

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial.

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial. www.ncbi.nlm.nih.gov 2015年に報告された、イスラエルのRCT 重症MRSA感染患者に対する、ST …

Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study

The Lancet Infectious Diseases Published: April 28, 2017 Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferio…

Journal Club : Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial

プレゼンターは呼吸器内科の先生 Journal Club : Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial www.ncbi.nlm.nih.gov

Journal Club : Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

今週は呼吸器内科の先生がプレゼンターでした。 Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting N Engl J Med 2016; 375:134-142 http://www.nejm.org/doi/full/10.1056/NEJMoa1515725

EMPIRICUS : Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.

Sepsis における抗真菌薬の重要な研究の1つ。 原則、好中球減少患者以外は、エンピリックな抗真菌薬投与を推奨しないかな。 Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida …

Journal Club : Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

Journal Club 毎週水曜日 呼吸器内科・代謝内科・専門看護師のみなさまと開催 ・この論文を取り上げた理由 PD-1は、20年に1度のパラダイムシフト薬であり、当院においてもレジメン選択に困る尿路上皮癌に対する論文であったため。標準はGC療法だが、腎機能低…

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

この研究は、素晴らしいです。しかし、ポリファーマシーに難しく影響します… 以下、荒削りPECO http://www.nejm.org/doi/full/10.1056/NEJMoa1511939 A Randomized Trial of Intensive versus Standard Blood-Pressure Control Article Tools The SPRINT Res…