3児の親さん薬剤師のブログ

とある薬剤師です。感染症治療を考える素材をちょこっと提供。https://note.mu/twin1980。

Clostridioides difficile infection

Effectiveness of Oral Vancomycin for Prevention of Healthcare Facility-Onset Clostridioides difficile Infection in Targeted Patients During Systemic Antibiotic Exposure

CIDに報告された、CDI予防に対する単施設RCT academic.oup.com

Use of oral vancomycin for Clostridioides difficile Infection (CDI) and the risk of vancomycin-resistant Enterococci (VRE)

CIDに報告された、米国での10年レトロ研究。 academic.oup.com

Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial

LIDに報告された、CDI予防薬のribaxamaseについてのplacebo RCT P2 www.sciencedirect.com

Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials

LIDからP3 RCT Patients received either oral cadazolid 250 mg twice daily with vancomycin-matching placebo capsule four times daily or oral vancomycin 125 mg four times a day with cadazolid-matching placebo suspension twice daily for 10 day…

Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis

LIDに報告された、CDI治療に関する治療法比較のネットワークメタ。 24試験、13治療法をごちゃっと。 www.ncbi.nlm.nih.gov

Do Probiotics Prevent C. difficile-Associated Diarrhea in Patients receiving Antibiotics?

Cochrane Database Syst rev 2017 Dec 19; 12:CD006095. (https://doi.org/10.1002/14651858.CD006095.pub4) についての NEJM JW. 感想 プロバイオ有用かも。 子供のNNT20。 Probiotics should not be given to patients who are immunocompromised, are pre…

Low Risk of Primary Clostridium difficile Infection With Tetracyclines: A Systematic Review and Metaanalysis

CIDから報告

Cost-effectiveness of Bezlotoxumab Compared With Placebo for the Prevention of Recurrent Clostridium difficile Infection

CIDに報告されたBezlotoxumabとプラセボの費用効果分析

Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial

LIDに報告された、CDIに対する、Extended-pulsed fidaxomicin vs vancomycinのP3b/4

Surotomycin versus vancomycin in adults with Clostridium difficile infection: primary clinical outcomes from the second pivotal, randomized, double-blind, Phase 3 trial

JAC に報告された、CIDに対するSurotomucin、P3 academic.oup.com

Hospital antimicrobial stewardship: the way forward

LIDで発表された Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis http://www.thelancet.com/journals…

The Effect of a Piperacillin/Tazobactam Shortage on Antimicrobial Prescribing and Clostridium difficile Risk in 88 US Medical Centers

CIDに発表された、PIP/TAZとCDI の関連についての報告

Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis

Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis http://www.thelancet.com/journals/laninf/article/…

Journal Club : MODIFY I and MODIFY II ; Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

Journal Club : Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection. MODIFY I and MODIFY II 今週のプレゼンターは、感染症看護専門看護師 2017年1月NEJMに報告された、日本を含む30カ国322施設におけるC. difficile の初感染また…

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. www.ncbi.nlm.nih.gov 2016年JAMAに報告された、カナダ6施設によるCDI…

Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study

The Lancet Infectious Diseases Published: April 28, 2017 Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferio…

【定期】Clostridium difficile infection

再発例が最近多し… 研修医の先生と抗菌薬について協議 再発例の対応は、毎回悩んでしまいますね。 UpToDate

CDI RCT ちょこっとまとめ

新しいRCTも増えてきたので、 吟味前にここ数年分と有名なCDI系RCT論文を ザックリ整理整頓 CDI 治療 どこに向かうのだろうか? ちな、Free論文多い気がしますね。

Clostridium difficile infection

2016はBack to Basic Clostridium difficile infection 治療の復習 UpToDate より引用

CDI 治療の復習

消化器医師とCDI治療についてdiscussion CDIは5大院内感染の1つであり 重要なので、学生と復習 以下は、本日のUp To Date より引用