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akinohanayuki日記

自分が興味あることを書いています. 主に感染領域. 二次利用は自己責任でお願いします. 博士(薬学). 感染制御専門薬剤師.

感染症論文ピックアップ

SOLO I : Single-dose oritavancin in the treatment of acute bacterial skin infections.

SOLO I : Single-dose oritavancin in the treatment of acute bacterial skin infections. www.ncbi.nlm.nih.gov 2014年 NEJMに報告された、急性細菌性皮膚/皮膚組織感染症に対するoritavancinとvancomycinを比較したRCT。

ESTABLISH-2 : Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.

ESTABLISH-2 : Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial. www.ncbi.nlm.nih.gov 2014年 Lancet Inf Disに…

ESTABLISH-1 : Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial.

ESTABLISH-1 : Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial. www.ncbi.nlm.nih.gov 2013年 JAMAに報告された、国際共同(アジアは含まれない)81施設 による…

Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.

Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. 2016年 JAMAに報告された、米国nursing home 21施設における高齢者細菌尿・膿尿に対するクランベリーカプセル vs プラセボを比…

Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial.

Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenicvertebral osteomyelitis: an open-label, non-inferiority, randomised, controlledtrial. 2015年 (Epub2014年) Lancetに報告された、フランス71施設における化膿性脊椎炎患者…

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. www.ncbi.nlm.nih.gov 2015年JAMAに報告された、スペイン3施設によ…

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. www.ncbi.nlm.nih.gov 2015年Lancetに報告された、スイス7施設による成人の市中肺炎に対するプレドニゾ…

Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL).

SOLITAIRE-ORAL : Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial. www.ncb…

Antibiotic treatment strategies for community-acquired pneumonia in adults.

CAP-START : Antibiotic treatment strategies for community-acquired pneumonia in adults. www.ncbi.nlm.nih.gov 2015年NEJMに報告された、オランダ7施設による成人の市中肺炎に対する抗菌薬治療戦略.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. www.ncbi.nlm.nih.gov 2016年JAMAに報告された、カナダ6施設によるCDI…

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial. www.ncbi.nlm.nih.gov 2016年CIDに報告された、ベトナム2施設によるデング熱に対するRCT。 スタチンとプラセボの比較。スタチンの抗炎…

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. www.ncbi.nlm.nih.gov 2015年NEJMに報告された、米国4施設による単純性皮膚感染症に対するRCT。 クラシカルなSTとクリンダマイシン比較。

Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess.

Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. www.ncbi.nlm.nih.gov 2016年NEJMに報告された、米国5施設による単純性皮膚膿瘍に対するRCT。 クラシカルなSTのプラセボ比較。

CAMERA : Combination of Vancomycin and β-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial.

CAMERA study Combination of Vancomycin and β-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial. オーストラリア7施設によるMRSA菌血症に対する併用療法パイロットRCT 新薬…

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial.

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial. www.ncbi.nlm.nih.gov 2015年に報告された、イスラエルのRCT 重症MRSA感染患者に対する、ST …

The Use of Noncarbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase Infections

The Use of Noncarbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase Infections Clin Infect Dis (2017) 64 (7): 972-980. https://academic.oup.com/cid/article-abstract/64/7/972/2957271/The-Use-of-Noncarbapenem-Lactams-for-th…

Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study

The Lancet Infectious Diseases Published: April 28, 2017 Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferio…

Comparative Effectiveness of Cefazolin versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study

Comparative Effectiveness of Cefazolin versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study Clin Infect Dis. 2017 Mar 31. PMID: 2837931…

Comparative effectiveness of beta-lactams versus vancomycin for treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections among 122 hospitals.

少し古いCID論文を復習。 目的は、より良いMSSA菌血症治療を目指してプラクティスを見直しのためです。 CID 2015 Aug 1;61(3):361-7. doi: 10.1093/cid/civ308. Epub 2015 Apr 21. Comparative effectiveness of beta-lactams versus vancomycin for treatme…

EMPIRICUS : Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.

Sepsis における抗真菌薬の重要な研究の1つ。 原則、好中球減少患者以外は、エンピリックな抗真菌薬投与を推奨しないかな。 Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida …