3児の親さん薬剤師のブログ

とある薬剤師です。感染症治療を考える素材をちょこっと提供。https://note.mu/twin1980。

Antibiotic treatment versus no treatment for asymptomatic bacteriuria in kidney transplant recipients: a multicenter randomized trial

OFIDから、RCTの報告。

腎臓移植レシピエントにおける無症候性細菌尿症に対する抗生物質治療と無治療の比較:多施設無作為化試験

 

primary endpoint : acute graft pyelonephritis (AGP)

 

academic.oup.com

 

f:id:akinohanayuki:20190527060612j:plain

 

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Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial

Lancetに報告された、ANODEトライアル。

 

operative vaginal birth at 36 weeks gestation or later.

 

a single dose of intravenous amoxicillin and clavulanic acid

placebo (saline)

 

Primary outcome data were missing for 195 (6%) women.

Significantly fewer women allocated to amoxicillin and clavulanic acid had a confirmed or suspected infection (180 [11%] of 1619) than women allocated to placebo (306 [19%] of 1606; risk ratio 0·58, 95% CI 0·49–0·69; p<0·0001).

 

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30773-1/fulltext?utm_campaign=lancet&utm_content=91541263&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292

 

f:id:akinohanayuki:20190522053559j:plain

 

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Efficacy and safety of intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis (CHOICE): a single-centre, open-label, randomised, controlled, non-inferiority trial

LIDに報告された、CHOICE試験。

 

小児蜂窩織炎に対する在宅CTRX vs 病院fluclxacillin。

単施設RCT、非劣勢の検討。

 

・CTRX  (50 mg/kg once daily) 

・flucloxacillin (50 mg/kg every 6 h)

 

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30729-1/fulltext

 

f:id:akinohanayuki:20190501074536j:plain

 

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