Ceftaroline vs VCM
Early Clinical Response [ Time Frame: 48 to 72 hours after initiation of study drug ]
Reduction of lesion size from baseline of at least 20%
600 mg IV (over 1 hour) every 12 hours for renal function > 50 mL/min, adjusted for renal function based on package insert for no more than 14 days.
Dosed by institutional pharmacy protocol to reach goal trough level of 10 - 20 mg/L steady state concentration for no more than 14 days.